type iv collagen การใช้

• Skin contains type IV collagen in a'556'network.
• The lamina densa is the central layer consisting of type IV collagen and laminin.
• This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes.
• Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins.
• Staining with anti-type IV collagen antibodies or anti-type VII collagen antibodies reveals bright, thick bands at the dermoepidermal junction.
• Cleaves type IV collagen at Ala 73-Gln in alpha1 ( IV ) and at Gly 7-Leu in alpha2 ( IV)
• More specifically, MMP-2 ( along with MMP-9 ) is capable of degrading type IV collagen, the most abundant component of the basement membrane.
• The glomerulus has a basement membrane consisting mainly of laminins, type IV collagen, agrin and nidogen, which are synthesized and secreted by both endothelial cells and podocytes.
• Gene therapy has been frequently discussed, but delivering it to the podocytes in the glomerulus that normally produce the type IV collagen in the glomerular basement membrane is challenging.
• The molecular basis for thin basement membrane disease has yet to be elucidated fully; however, defects in the gene encoding the a4 chain of type IV collagen have been reported in some families.
• This gene encodes a kinase also known as Goodpasture antigen-binding protein that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen.
• From recent studies, COL4A1 ", suggesting genetic predisposition within the family, that encodes type IV collagen ?1 chain has shown to be associated with and present in patients with porencephaly . " COL4A1 " mutation causes a variety of phenotypes, including porencephaly, infantile hemiplegia, and cerebral small vessel diseases involving both stroke and infarction.
• It binds fibril-forming collagens and primarily type IV collagen, but also collagen of types I, VI, VIII . It is expressed mainly in epithelial cells and leukocytes and expression rate changes due to cell cycle phase . Functions include : mammary gland development; arterial wound repair; regulation of cell proliferation, cell adhesion and MMP expression; kidney function, differentiation and function of leukocytes.
• Matrix metalloproteinases ( MMP ), which catalyse extracellular matrix degradation, have N-terminal domains that resemble PGBD . Examples are gelatinase A ( MMP-2 ), which degrades type IV collagen, stromelysin-1 ( MMP-3 ), which plays a role in arthritis and tumour invasion, and gelatinase B ( MMP-9 ) secreted by neutrophils as part of the innate immune defence mechanism.